Biomarkers of Effect

Analyte Full Name Parent Compound Matrix Method Reference
Amino Acids
Arg Arginine Arg P LC-MS/MS
ADMA Asymmetric Dimethyl-arginine Arg P LC-MS/MS
SDMA Symmetric Dimethyl-arginine Arg P LC-MS/MS
L-NMMA L-N-Monomethyl-arginine Arg P LC-MS/MS
Cit Citrulline Cit P LC-MS/MS
Hcy Homo-cysteine Met P LC-MS/MS
Met Methionine Met P LC-MS/MS
Ntyr 3-Nitro-tyrosine Tyr EBC LC-MS/MS
Mercapturic acids
DHNMA 1,4-Dihydroxy-2-nonene-mercapturic acid HNE U LC-MS/MS
HNE-MA 4-Hydroxynonenal-mercapturic acid HNE U LC-MS/MS
HNALMA 4-Hydroxy-2-nonenelactone mercapturic acid HNE U LC-MS/MS
HNAMA 4-Hydroxy-2-nonenoic acid-mercapturic acid HNE U LC-MS/MS
Oxidative Stress/Inflammation
b-Carotene beta-Carotene Oxid. Stress P,S HPLC-PM Troebs, 2002
Vit C Ascorbic acid Oxid. Stress P,S HPLC-PM Troebs, 2002
Vit E alpha-Tocopherol Oxid. Stress P,S HPLC-PM Troebs, 2002
8-OHdG 8-hydroxy-2-deoxy-guanosine Oxid. Stress U LC-MS/MS Renner, 1999
4-HNE 4-hydroxy-2-nonenale

Lipid peroxidation/

Oxid. stress

U
GC-MS
MDA Malondialdehyde

Lipid peroxidation/

Oxid. Stress
U GC-MS
PGF2a prostaglandin F2 alpha Oxid. Stress U LC-MS/MS
8-iso-PGF2a

8-epi/iso-prostaglandin

F2 alpha

Oxid. Stress U LC-MS/MS
Sterz, 2012
2,3-dn-8-iso-PGF2a 2,3-dinor-8-epi/iso-prostaglandin F2 alpha Oxid. Stress
U LC-MS/MS
Sterz, 2012
12-HETE

12-hydroxyeicosa-

tetraenoic acid

Inflammation, 12-HpETE U LC-MS/MS

Sterz, 2012

LTE4 Leukotriene E4 Inflammation, LTC4 U LC-MS/MS Sterz, 2012
PGE-M tetranor-PGE metabolite Inflammation, PGE2 U LC-MS/MS Sterz, 2012
PGD-M tetranor-PGD metabolite Inflammation, PGD2 U LC-MS/MS
11-dh-TXB2 11-dehydro-thromboxane B2 Inflammation, TXA2 U LC-MS/MS Sterz, 2012
2,3-dn-TXB2 2,3-dinor-thromboxane B2 Inflammation, TXA2 U LC-MS/MS Sterz, 2012
Lipids
PC (39 molecular species) phosphatidylcholine

Membrane lipid

precursor of signalling lipids

P LC-MS/MS

Mueller, 2014

PE (40 molecular species)

phosphatidyl-

ethanolamine

Membrane lipid

precursor of signalling lipids

P LC-MS/MS

Mueller, 2014

Ketone bodies
Acetone

Acetone

Energy metabolism
P,brain
GC-MS
Acetoacetate Acetoacetate Energy metabolism P,brain GC-MS
3-OH-Butyrate 3-OH-Butyrate Energy metabolism P,brain GC-MS
Bile acids
CA

cholic acid

Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
CDCA chenodeoxycholic acid Lipid absorp., endocrine function (Chol) P,S (U) LC-MS/MS Scherer, 2009
DCA deoxycholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
LCA lithocholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
UDCA ursodeoxycholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
HDCA hyodeoxycholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
GCA glycocholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
GCDCA

glycochenodeoxycholic

acid

Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
GDCA glycodeoxycholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
GLCA glycolithocholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
GUDCA

glycoursodeoxycholic

acid

Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
GHDCA glycohyodeoxycholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
TCA taurocholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
TCDCA

taurochenodeoxycholic

acid

Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
TDCA taurodeoxycholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
TLCA taurolithocholic acid Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
TUDCA

tauroursodeoxycholic

acid

Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
THDCA

taurohyodeoxycholic

acid

Lipid absorp., endocrine function (Chol) P,S,(U) LC-MS/MS Scherer, 2009
Creatinine
CREA Creatinine

Physiological (urine flow normalization)

U PM

Abbreviations: B-Blood, EB-Exhaled breath, EBC-Exhaled breath condensate, F-Feces; P-Plasma, S-Serum, Sa-Saliva, U-Urine, W-swipe sample.